Answer:
Native peoples of America had no immunity to the diseases that European explorers and colonists brought with them. Diseases such as smallpox, influenza, measles, and even chicken pox proved deadly to American Indians.
Explanation:
De Soto's path through the Mississippian cultures of what is now the southeast United States spread disease among the local inhabitants, diminished native food supplies, and led to a reduction in native populations. Resisting tribes found themselves under vicious attack by Spanish soldiers.
